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目的初步评价无偿献血者接种甲型H1N1型流感(简称甲流)疫苗的效果,为临床采集、储备甲流抗体血浆提供依据。方法对2010年1月—2010年2月的1027名东莞市无偿献血者分为甲流疫苗接种组(n=899)和对照组(n=128),应用ELISA法检测2组的人H1N1IgG抗体,并对检测结果进行统计分析。结果抗-H1N1阳性率:甲流疫苗接种组为77.53%(697/899),对照组为15.63%(20/128),2组比较具统计学意义(χ2=203.76,P<0.01);抗-H1N1阳性结果S/CO值,甲流疫苗接种组为1.27±0.18,对照组为1.08±0.07(t=4.71,P<0.01);甲流疫苗接种者中,接种时间71—80d组的抗-H1N1阳性率、S/CO值均高于接种时间小于70d的各组。在甲流疫苗接种组中37例自诉有接种副反应,占4.12%,但无严重副反应。结论无偿献血者接种甲流疫苗安全且能有效产生抗-H1N1IgG,建议在接种疫苗70d后采集甲流抗体血浆。
Objective To evaluate the effect of unpaid blood donors inoculation of influenza A (H1N1) vaccine for the purpose of providing a basis for the clinical collection and stocking of plasma of influenza A virus. Methods A total of 1027 blood donors from Dongguan City from January 2010 to February 2010 were divided into two groups: control group (n = 899) and control group (n = 128). ELISA was used to detect human H1N1 IgG antibody , And the test results for statistical analysis. Results The positive rate of anti-H1N1 was 77.53% (697/899) in the control group and 15.63% (20/128) in the control group. The positive rates of anti-H1N1 in the two groups were statistically significant (χ2 = 203.76, P <0.01) -H1N1 positive results of S / CO value, a flow vaccination group was 1.27 ± 0.18, the control group was 1.08 ± 0.07 (t = 4.71, P <0.01); Influenza A vaccination, vaccination time 71-80d group -H1N1 positive rate, S / CO values were higher than inoculation time less than 70d of each group. In a stream of vaccination group, 37 cases of private prosecution have vaccination side effects, accounting for 4.12%, but no serious side effects. Conclusion It is safe and effective for anti-H1N1 IgG to be vaccinated by non-profit blood donors. It is recommended to collect the blood plasma of antibody A after 70 days of vaccination.