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目的 研究镁盐在急性心肌梗死(AMI)后室性心律失常时的防治作用。方法 我们应用硫酸镁快速静滴、后缓慢给药,每d2.5g,连用7d,并采用了对照组。分再通治疗组(A_1)、未通治疗组(A_2);再通对照组(B_1)和未通对照组(B_2)。结果 室性心律发生率分别是A_1占14.7％(10/68),B_1占45.1％(32/71);A_2占10％(3/30),B2占36.4％(12/33)。A_1与B_1比较差异显著(P<0.01);A_2与B_2比较亦具有显著差异(P<0.01)。结论AMI早期补镁不仅能明显降低AMI引起的室性心律失常发生率,而且也能非常有效地抑制溶栓后再灌注性心律失常的发生。
Objective To study the preventive and therapeutic effects of magnesium salt on ventricular arrhythmia after acute myocardial infarction (AMI). Methods We applied rapid intravenous infusion of magnesium sulfate, after slow dosing, d2.5g, once every 7d, and the control group. The treatment group (A_1) and the non-treatment group (A_2) were re-treated with B_1 and control groups (B_2). Results The rates of ventricular arrhythmia were 14.7% (10/68) in A_1, 45.1% (32/71) in B_1, 10% (3/30) in A_2 and 36.4% (12/33) in B2. The difference between A_1 and B_1 was significant (P <0.01). There was also significant difference between A_2 and B_2 (P <0.01). Conclusion Early magnesium supplementation can not only significantly reduce the incidence of ventricular arrhythmias induced by AMI, but also inhibit the occurrence of reperfusion arrhythmia after thrombolytic therapy.