论文部分内容阅读
共轭二烯的1,2-双官能化反应是重要的均相催化反应之一.反应所得的双官能化产物广泛存在于天然产物和生物活性的化合物中,也是很多重要的有机中间体的来源;而且双官能化产物中还保留有一个可以继续转化的双键,可以更灵活地构建我们所需的目标结构,或继续官能化,从而实现简单二烯的多官能化反应,得到邻近的多官能化产物.此领域中主要的难点在于反应中区域选择性、化学选择性和立体选择性等复杂选择性的控制.近年来,随着金属有机化学的不断发展,已陆续实现了金属钯、铜、铁或银催化的共轭二烯的1,2-双官能化反应,而且有些报道中通过引入手性配体成功地实现了共轭二烯的不对称1,2-双官能化反应.本综述将对近年来金属催化的共轭二烯的1,2-双官能化反应的研究进展进行重点介绍.
The 1,2-bifunctionalization of conjugated dienes is one of the important homogeneous catalysis reactions, and the bifunctional products obtained by the reaction exist widely in natural products and bioactive compounds and also as important organic intermediates Source; and the bifunctional product retains a double bond that can continue to be converted, allowing more flexibility in constructing the desired target structure or continuing the functionalization to allow for multifunctionalization of the simple diene resulting in the formation of adjacent Multi-functionalized products.The main difficulty in this field is the complex and selective control of regioselectivity, chemoselectivity and stereoselectivity in the reaction.In recent years, with the continuous development of metal organic chemistry, metal palladium , Copper, iron or silver-catalyzed 1,2-bifunctionalization of conjugated dienes, and in some reports asymmetric 1,2-bifunctionalization of conjugated dienes has been successfully achieved by the introduction of chiral ligands This review will highlight recent advances in 1,2-bifunctional reactions of metal-catalyzed conjugated dienes.