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目的：研究评价法莫替丁缓释片在健康人体内的生物利用度。方法：以高效液相色谱法测定血药浓度，用３Ｐ８７程序处理数据。结果：单剂量给药，本品的达峰时间为（７．１２±０．４０）ｈ，峰浓度为（５８．６９±４．３６）ｎｇ·ｍｌ－１，相对生物利用度为（１１７．０±８．９）％；多剂量给药达稳态后，本品的峰浓度为（７０．７２±４．６１）ｎｇ·ｍｌ－１，血药浓度波动度为（１２１．６±１１．４）％，相对生物利用度为（１１７．９±２３．４６）％。结论：法莫替丁缓释片与市售普通片基本生物等效。
Objective: To evaluate the bioavailability of famotidine sustained-release tablets in healthy volunteers. Methods: The plasma concentration was determined by HPLC, and the data was processed by 3P87 program. Results: The peak time of this product was (7.12 ± 0.40) h, the peak concentration was (58.69 ± 4.36) ng · ml-1, the relative bioavailability was (117 .0 ± 8.9)%. After the multi-dose administration reached steady state, the peak concentration of this product was (70.72 ± 4.61) ng · ml-1, and the fluctuation of plasma concentration was (121.6 ± 11.4)%, the relative bioavailability was (117.9 ± 23.46)%. Conclusion: Famotidine sustained release tablets are commercially bioavailable equivalent to commercial tablets.