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当前治疗慢性丙型肝炎病毒感染的方法是以α干扰素或干扰素与其他抗病毒药联合应用为基础。但这仅对少数经选择病人有效。有报道,应用熊去氧胆酸(UDCA)长期治疗可改善肝功能及其结构,尤其是有胆汁郁积者。此文旨在研究:①评估UDCA治疗对不适用IFN或IFN无效的HCV相关性慢性肝病病人肝功能的长期疗效;②研究慢性肝病严重度对UDCA
Current methods of treating chronic hepatitis C virus infection are based on interferon-alpha or interferon in combination with other antiviral agents. But this is only valid for a small number of selected patients. It has been reported that long-term treatment with ursodeoxycholic acid (UDCA) can improve liver function and its structure, especially in patients with cholestasis. The purpose of this paper is to study: (1) to evaluate the long-term effect of UDCA on liver function in HCV-related chronic liver disease patients who are not eligible for IFN or IFN; (2) to study the effect of severity of chronic liver disease on UDCA