内质网(endoplasmic reticulum,ER)应激是细胞应激的重要组成部分,表现为内质网腔内错误折叠或未折叠蛋白的蓄积以及细胞内Ca2+平衡紊乱,与应激细胞的损伤或凋亡直接相关。胰岛B细胞具有高度发达和活跃的内质网体系,因此对ER应激尤为敏感。近年来的研究证实,ER应激在胰岛素抵抗 Endoplasmic reticulum (ER) stress is an important part of cellular stress, which is characterized by the accumulation of misfolded or unfolded proteins in the lumen of the endoplasmic reticulum, as well as the imbalance of intracellular Ca2 + balance and the damage or apoptosis of stressed cells Death is directly related. Islet B cells have a highly developed and active endoplasmic reticulum and are therefore particularly sensitive to ER stress. Recent studies have confirmed that ER stress is in insulin resistance