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目的 :探讨IGF ImRNA在结直肠癌组织中的表达。方法 :采用RT PCR方法检测 2 8例结直肠癌组织及癌周正常组织IGF ImRNA的表达。结果 :2 8例结直肠癌中 ,IGF ImRNA表达阳性者 2 0例 ,癌周组织仅 3例阳性 ,癌组织中的表达率明显高于癌周组织 (P <0 .0 1) ;C、D期癌表达率明显高于A、B期癌 (P <0 .0 1)。结论 :IGF I在结直肠癌组织中存在广泛的表达 ,IGF ImRNA的表达与结直肠癌的转移有关
Objective: To investigate the expression of IGF I mRNA in colorectal cancer. Methods : The expression of IGF I mRNA was detected in 28 colorectal cancer tissues and normal tissues by RT PCR. RESULTS: Twenty-eight cases of colorectal cancer had positive expression of IGF I mRNA in 20 cases, and only 3 cases in the pericancerous tissue were positive. The expression rate in cancer tissue was significantly higher than that in the pericancerous tissue (P < 0.01); The expression rate of stage D cancer was significantly higher than that of stage A and B cancers (P < 0.01). Conclusion: IGF I is widely expressed in colorectal cancer tissues. The expression of IGF I mRNA is related to the metastasis of colorectal cancer.