Marie共济失调又称遗传性痉挛性共济失调,属常染色体显性遗传,是一种少见的家族性遗传性疾病。本文报告一家系12例调查结果。先证者男,33岁,因走路不稳、言语不清2年,加重1年入院。迫问病史,发现其家族中有12人患病(见家系图)。 Marie ataxia, also known as hereditary spastic ataxia, is an autosomal dominant inheritance, is a rare familial genetic disease. This article reports a family of 12 cases of the survey results. Male proband, 33 years old, due to walking unsteadiness, verbal ill-defined 2 years, increased 1 year admission. Forced to ask a medical history, found that 12 people in their family (see family diagram).