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目的评价国产奥美拉唑对肝源性溃疡(HU)的疗效和副作用。方法对243例确诊肝硬化患者经胃镜检查有活动期溃疡患者46例,每日晨服国产奥美拉唑20 mg,疗程4~6周,观察胃镜下溃疡愈合、临床症状好转和副作用情况,并与同期消化性活动期溃疡(PU)43例对比。结果4周愈合率HU组中,十二指肠球部溃疡(DU)为71.43%(20/28),胃溃疡(GU)为55.56%(10/18);PU组中DU与GU为100.00%(31/31与12/12);两组比较差异有统计学意义(P<0.005)。6周愈合率HU中DU为85.71%(24/28),GU为88.89%(16/18)。肝功能Child C级者溃疡愈合率明显降低。结论国产奥美拉唑治疗HU的疗效较好,但比PU差,且疗程应比PU长,尤其肝功能Child C级者。未见明显副作用。
Objective To evaluate the efficacy and side effects of domestic omeprazole on liver-derived ulcer (HU). Methods Forty-four patients with active cirrhosis who underwent endoscopy and gastroscopy were enrolled in the study. Forty-six patients with active ulcer were enrolled in this study. Domestic omeprazole 20 mg daily was taken for 4 to 6 weeks. The ulcer healing, clinical signs and side effects were observed. And with the same period of peptic ulcer (PU) 43 cases of contrast. Results In the HU group, the duodenal ulcer (DU) was 71.43% (20/28) and the gastric ulcer (GU) was 55.56% (10/18) % (31/31 and 12/12). There was significant difference between the two groups (P <0.005). The DU healing rate in HU at 6 weeks was 85.71% (24/28) and GU was 88.89% (16/18). Child C grade liver function ulcer healing rate was significantly lower. Conclusion Domestic omeprazole treatment of HU better curative effect, but worse than the PU, and the treatment should be longer than PU, especially liver function Child C grade. No obvious side effects.