论文部分内容阅读
Wegener肉芽肿是一种系统性炎症性疾病,其临床表现不特异。眼部表现约为1/6患者的首发症状,而且大多数患者最终都将出现眼部症状。眼前节和后节的任何组织都可受累。抗中性粒细胞胞浆抗体(尤其是抗蛋白酶-3)的发现,改变了临床上对Wegener肉芽肿可疑患者的评价方法。口服环磷酰胺和糖皮质激素治疗Wegener肉芽肿可降低发病率,提高生存率。有人正在研究三甲氧苄氨嘧啶-磺胺甲异恶唑对降低Wegener肉芽肿复发次数及严重程度的作用。
Wegener’s granulomatosis is a systemic inflammatory disease, its clinical manifestations are not specific. Eye performance is about 1 in 6 patients with the first symptom, and most patients will eventually have ocular symptoms. Any organization in the anterior or posterior segment can be affected. The discovery of anti-neutrophil cytoplasmic antibodies (especially anti-protease-3) has changed the clinical evaluation of patients with suspected Wegener’s granulomatosis. Oral cyclophosphamide and glucocorticoid treatment Wegener granulomatosis can reduce the incidence and improve survival. Trimethoprim-sulfamethoxazole is being studied to reduce the number and severity of Wegener’s granuloma relapse.