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血管紧张素Ⅱ(AngⅡ)是肾素-血管紧张素系统(RAS)中的主要效应分子,AngⅡ除了调节机体血压、维持水电解质平衡外,还可以上调多种致炎性因子的表达,在促进肺纤维化、肺实质细胞凋亡、炎性反应、肺水肿等方面发挥着一定作用,与ALI发生、发展及预后关系密切。通过深入研究局部肺组织中AngⅡ及其相关受体信号通路在ALI中的致病机制和作用,可能为ALI临床防治提供新的思路和方向。
Ang Ⅱ is the main effector molecule in renin-angiotensin system (RAS). In addition to regulating body blood pressure and maintaining water-electrolyte balance, AngⅡ can up-regulate the expression of many inflammatory factors, Pulmonary fibrosis, pulmonary parenchymal cell apoptosis, inflammatory reaction, pulmonary edema and other aspects play a role, with the ALI occurrence, development and prognosis are closely related. It is possible to provide new ideas and directions for the clinical prevention and treatment of ALI by studying the pathogenesis and role of Ang II and its related receptor signaling pathways in local lung tissue.