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目的研究十堰市单增李斯特菌分离株的同源性和耐药性,为追溯传染源和临床用药提供参考依据。方法对单增李斯特菌分离株进行PFGE分型,然后用E-test法对氨苄西林等13种抗生素进行耐药性分析。结果 26株单增李斯特菌可分为13个PFGE亚型,相同PFGE型的菌株为同一来源。分别有45.15%和19.23%的菌株对磺胺嘧啶和环丙沙星耐药,对这2种抗生素均耐药的菌株有2株,为多重耐药菌株。结论十堰市单增李斯特菌对一些抗生素存在较严重的耐药性,应加强对单增李斯特菌等食源性致病菌的监测,避免其污染水体而影响南水北调水源区水质。
Objective To study the homology and drug resistance of Listeria monocytogenes isolates in Shiyan City and provide a reference for tracing the source of infection and clinical medication. Methods Isolates of Listeria monocytogenes were genotyped by PFGE, and then drug resistance of 13 antibiotics such as ampicillin were analyzed by E-test. Results 26 strains of Listeria monocytogenes could be divided into 13 PFGE subtypes, and the same PFGE type strains were the same source. 45.15% and 19.23% strains were resistant to sulfadiazine and ciprofloxacin, respectively. There were 2 strains resistant to these two antibiotics, which were multi-drug resistant strains. Conclusion Listeria monocytogenes in Shiyan City is more resistant to some antibiotics. Therefore, the monitoring of foodborne pathogens such as Listeria monocytogenes should be strengthened to avoid the pollution of water body and the water quality in the water source areas of the South-to-North Water Diversion Project.