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本实验观察了国产加贝酯对大鼠实验性急性胰腺炎的治疗效果,并与进口药品FOY及抑肽酶作了比较。结果表明国产加贝酯能提高急性胰腺炎大鼠的存活率;抑制病鼠血清淀粉酶、脂肪酶活性及尿素氨水平的升高;改善病鼠胰腺组织病变程度,减轻脂肪组织坏死。其疗效与FOY相同,优于抑肽酶。可为临床上一种治疗急性胰腺炎的新药。
This experiment observed the efficacy of home-made Gabexate on experimental acute pancreatitis in rats and compared it with imported drugs FOY and aprotinin. The results showed that domestic Gabexate can improve the survival rate of rats with acute pancreatitis; inhibition of serum amylase, lipase activity and urea ammonia levels increased; improve the degree of pancreatic lesions in rats, reduce fat tissue necrosis. Its efficacy is the same as FOY, better than aprotinin. It can be a new drug for the treatment of acute pancreatitis in clinical practice.