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目的探讨人乳头瘤病毒16、18(HPV16、18)感染与乳腺癌发生发展的关系。方法选取乳腺癌和乳腺增生患者各50例,其中乳腺癌患者中浸润性导管癌25例、单纯癌18例、其他类型7例,采用原位杂交法检测所有患者人乳头瘤病毒16、18的表达,对两组患者及不同组织学分型乳腺癌患者中人乳头瘤病毒16、18表达情况进行统计分析。结果乳腺癌组HPV16感染率、HPV18感染率及HPV16、HPV18感染率分别为36.00%、20.00%和18.00%,乳腺增生组三者感染率分别为8.00%、4.00%和4.00%,两组差异有统计学意义(P<0.05)。浸润性导管癌、单纯癌及其他类型乳腺癌三组患者中HPV16感染率、HPV18感染率及HPV16、HPV18感染率差异均无统计学意义(P>0.05)。结论 HPV16、18感染与乳腺癌的发生发展密切相关,但乳腺癌的组织分型与HPV16、18感染无明显关系。
Objective To investigate the relationship between human papillomavirus (HPV) 16,18 (HPV16,18) infection and the development of breast cancer. Methods Fifty patients with breast cancer and hyperplasia of mammary gland were selected. Among them, 25 were invasive ductal carcinoma, 18 were simple carcinoma and 7 were other types. The in situ hybridization assay was performed on all patients with HPV16,18 Expression, the two groups of patients and different histological breast cancer patients in the expression of HPV16,18 statistical analysis. Results The infection rates of HPV16, HPV18 and HPV16, HPV18 in breast cancer group were 36.00%, 20.00% and 18.00%, respectively. The infection rates in breast hyperplasia group were 8.00%, 4.00% and 4.00% Statistical significance (P <0.05). In invasive ductal carcinoma, simple carcinoma and other types of breast cancer three groups of patients with HPV16 infection rate, HPV18 infection rate and HPV16, HPV18 infection rate difference was not statistically significant (P> 0.05). Conclusion HPV16,18 infection is closely related to the occurrence and development of breast cancer. However, there is no significant correlation between the tissue typing of breast cancer and HPV16,18 infection.