以 1-二甲胺基 - 2 ,3 -二氯丙烷盐酸盐水溶液与硫代硫酸钠为主要原料 ,合成制得 2 -二甲胺 - 1-硫代磺酸钠基 - 3-硫代磺酸基丙烷。先在 0～ 3℃ ,盐酸盐水溶液中加入定量NaOH制得氯化物 ,再进行硫代硫酸化反应。用正交设计试验法优选出硫代硫酸化反应最佳工艺条件为 :氯化物pH值 6 .8,反应温度 6 9℃ ,反应时间 3 .5h ,甲醇用量为每摩尔氯化物 6 0 0g,反应收率从目前工业生产的 85 .4%提高到 95 .8%。 The main raw materials of 1 - dimethylamino - 2, 3 - dichloropropane hydrochloride and sodium thiosulfate were synthesized to obtain 2 - dimethylamine - 1 - sodium thiosulfonate - 3 - thio Sulfonopropane. First in 0 ~ 3 ℃, hydrochloric acid solution was added quantitative NaOH chloride obtained, and then thiosulfate reaction. Orthogonal design test was used to optimize the optimum conditions for the thiosulfation reaction: chloride pH value of 6 .8, the reaction temperature of 6 9 ℃, the reaction time of 3.5 h, the amount of methanol per mol of chloride 6 0 0g, The yield of the reaction increased from 85.4% of the current industrial production to 95.8%.