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目的观察青岛市慢性丙型肝炎患者基因型的分布特点,探究丙型肝炎病毒(HCV)基因型与患者年龄、性别之间的关系以及HCV基因型与利巴韦林联合聚乙二醇干扰素治疗效果的关系。方法采用利巴韦林联合聚乙二醇干扰素的标准方案,对157例患慢性丙型肝炎初治患者进行治疗,应用PCR方法检测HCV基因分型,治疗后评价持续病毒学应答情况。结果 157例丙肝患者中HCV 1型占64.33%,HCV 2型占28.03%,HCV 3型占6.37%,HCV 6型占1.27%,未见HCV基因4型、5型。各基因型间男女患者所占比例差异无统计学意义(P>0.05);基因1型、2型、3型、6型的平均年龄分别为(50.69±15.22)岁、(48.34±14.63)岁、(37.20±3.71)岁、(38.50±2.12)岁,差异无统计学意义;HCV 2型患者获得SVR率明显高于HCV 1型,差异有统计学意义[χ2=7.998,χ20.05(1)=3.841,P<0.05]。结论青岛地区HCV基因型以l型为主,其次是2型,未见基因4型、5型,HCV 1型患者对标准治疗方案的疗效较HCV2型差。
Objective To observe the distribution of genotypes in patients with chronic hepatitis C in Qingdao and to explore the relationship between HCV genotypes and age and sex of patients and the relationship between genotypes of HCV and ribavirin combined with pegylated interferon Therapeutic effect of the relationship. Methods Fifty-seven patients with initial treatment of chronic hepatitis C were treated with ribavirin combined with peginterferon. HCV genotypes were detected by PCR and the sustained virological response was evaluated after treatment. Results Among 157 HCV patients, HCV type 1 accounted for 64.33%, HCV type 2 accounted for 28.03%, HCV type 3 accounted for 6.37% and HCV type 6 accounted for 1.27%. No HCV genotypes 4 and 5 were found. There were no significant differences in the proportions of male and female genotypes among the genotypes (P> 0.05). The average genotypes of genotypes 1, 2, 3 and 6 were (50.69 ± 15.22) years and (48.34 ± 14.63) years , (37.20 ± 3.71) years old and (38.50 ± 2.12) years old, respectively. There was no significant difference in the SVR rate between HCV type 2 patients and HCV type 1 patients (χ2 = 7.998, χ20.05 ) = 3.841, P <0.05]. Conclusion The genotypes of HCV in Qingdao are mainly type l, followed by type 2, but no genotypes 4 and 5, and the efficacy of standard treatment in patients with HCV type 1 is worse than that of HCV2.