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作者研究抗组胺剂噻嗪铵甲基硫酸盐(Thiazi-namium methylsulfate,Ⅰ)栓剂的生物利用度,体内代谢产物和尿排泄物及其数量比率,确证(Ⅰ)栓剂存在首次通过效应。所用栓剂基质为亲脂性饱和脂肪酸(C_(12)～C_(18))的
The authors investigated the bioavailability of the antihistamine Thiazi-namium methylsulfate (I) suppository, the amount of metabolites and urinary excretion in vivo, and their quantitative ratios confirming the (I) first-pass effect of the suppository. The suppository base used was lipophilic saturated fatty acid (C_ (12) ~ C_ (18))