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目的:观察顽癣敌软膏抗炎和止痒的药理作用。方法:采用磷酸组织胺对豚鼠局部皮肤致痒耐受试验,观察该药的止痒作用;大鼠角叉菜胶性足跖炎症试验,观察该药的抗炎作用。结果:①顽癣敌软膏中、高剂量可明显提高磷酸组织胺对豚鼠局部皮肤致痒反应的致痒阈,有明显的止痒作用。②顽癣敌软膏各剂量组大鼠足跖的肿胀率均较模型组有明显的降低,并呈现剂量的相关性。同时中、高剂量组的肿胀率也均较空白基质组有明显的降低,与阳性药卡泊三醇软膏组相近。有明显的抑制非特异性炎症作用。结论:在本试验条件下,顽癣敌软膏具有明显的止痒作用,并对非特异性炎症的早期渗出与肿胀有明显的抑制作用。
OBJECTIVE: To observe the pharmacological effects of anti-inflammatory and antipruritic stamina ointment. Methods: Antihistamines were used to test the antipruritic effect of histamine phosphate on the local skin of guinea pigs. The antipruritic effect of the drug was observed. The carrageenan paw edema test was conducted to observe the anti-inflammatory effect of the drug. Results: ① stubborn ring enemy ointment, high dose can significantly improve the phosphorylation of histamine on the local skin itching Guinea pigs itch threshold, there is a clear anti-itch effect. (2) The swelling rate of foot and foot of rats in each dose of stubborn ointment was significantly lower than that of the model group, and showed a dose-related relationship. At the same time, the swelling rate of medium and high dose groups were significantly lower than blank matrix group, similar to the positive drug calcipotriol ointment group. There is obvious inhibition of non-specific inflammation. Conclusion: Under the test conditions, stubborn euphorbia ointment has obvious antipruritic effect and obviously inhibits early exudation and swelling of nonspecific inflammation.