X染色体连锁的凋亡抑制蛋白(X-linked inhibitor of apoptosis protein,XIAP)是凋亡蛋白抑制剂家族的一员,可通过抑制caspase的活性抑制细胞的凋亡。研究显示,X染色体连锁的凋亡抑制蛋白与卵巢癌细胞对化疗放疗的敏感性有关,下调X染色体连锁的凋亡抑制蛋白的表达可增加卵巢癌对顺铂等化疗药物的敏感性,此作用与癌细胞的p53状态有关。X染色体连锁的凋亡抑制蛋白引起的耐药可能与Akt,TRAIL途径有关。目前各种针对X染色体连锁的凋亡抑制蛋白的治疗正在研究中,有望成为卵巢癌综合治疗中的一个新途径。 X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis protein family, which can inhibit cell apoptosis by inhibiting caspase activity. Studies have shown that the X-linked inhibitor of apoptosis protein is related to the sensitivity of ovarian cancer cells to chemotherapy and radiotherapy. Down-regulation of the X-linked inhibitor of apoptosis protein may increase the sensitivity of ovarian cancer to chemotherapeutic drugs such as cisplatin. It is related to the p53 status of cancer cells. The resistance induced by the X-linked inhibitor of apoptosis protein may be related to the Akt and TRAIL pathways. Currently a variety of treatments for the X-linked inhibitor of apoptosis proteins are under study and is expected to become a new approach in the comprehensive treatment of ovarian cancer.