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目的观察急性脑梗死患者血脂、血浆纤维蛋白原(Fib)水平的变化,探讨其与脑梗死严重程度与预后的相关性。方法分别采用酶比色法、直接法检测56例急性脑梗死患者(ACI组)和45例非急性脑梗死患者(对照组)三酰甘油(TG)、总胆固醇(TCH)和高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,凝血酶比浊法检测Fib水平,并比较ACI组治疗前、后各指标水平的变化。结果 ACI组中TG、TCH、LDL-C、Fib水平明显高于对照组(P均<0.01),HDL-C低于对照组(P<0.05);随着ACI严重程度的增加,TG、TCH、LDL-C和Fib水平逐渐增高,HDL-C水平逐渐降低,ACI轻型组、中型组TG水平与重型组相比,差异均有统计学意义(P<0.05),轻型组TCH、LDL-C、HDL-C水平与重型组相比,差异有统计学意义(P<0.05),轻型组Fib水平与中型组、重型组相比,中型组与重型组相比,差异有统计学意义(P<0.05或<0.01)。结论监测ACI患者血脂、Fib水平的变化,对判断病情、预后及指导治疗有一定的意义。
Objective To observe the changes of serum lipids and fibrinogen (Fib) level in patients with acute cerebral infarction and to explore the correlation between the severity of cerebral infarction and the prognosis. Methods The contents of triglyceride (TG), total cholesterol (TCH) and high density lipoprotein (HDL) in 56 patients with acute cerebral infarction (ACI group) and 45 patients with non-acute cerebral infarction (HDL-C), low density lipoprotein cholesterol (LDL-C) and thrombin turbidimetry were used to detect the level of Fib. The changes of each index before and after ACI were compared. Results The levels of TG, TCH, LDL-C and Fib in ACI group were significantly higher than those in control group (all P <0.01), while HDL-C was lower in ACI group than in control group , LDL-C and Fib levels gradually increased, and HDL-C levels gradually decreased. There were significant differences in TG levels between ACI light and middle-sized groups (P <0.05) (P <0.05). The level of HDL-C in HDL-C group was significantly higher than that in the heavy group (P <0.05). The level of Fib in the light group was significantly higher than that in the medium group and the heavy group <0.05 or <0.01). Conclusion Monitoring the changes of blood lipids and Fib levels in patients with ACI has certain significance in judging the condition, prognosis and guiding therapy.