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目的观察听源性惊厥易感性大鼠惊厥发作时上丘内ＦＯＳ免疫阳性神经元的分布。方法实验动物分４组。ＰＳ组：电铃（１０６ｄＢ，１０～２０ｋＨｚ，６０ｓ）刺激下呈急性惊厥发作的惊厥鼠；ＰＮ组：非急性惊厥发作的惊厥鼠；ＷＳ组：电铃刺激的正常鼠；ＷＮ组：无电铃刺激的正常鼠。每组各５只。ＰＳ和ＷＳ组电铃刺激后存活２ｈ。结果①只有在ＰＳ大鼠的上丘可见有典型的ＦＯＳ样免疫阳性神经元，且其只分布在第Ⅳ、Ⅵ、Ⅶ层。②在ＰＳ大鼠上丘第Ⅳ层、第Ⅵ和Ⅶ层，ＦＯＳ样免疫阳性神经元多数位于尾侧段。结论本研究结果表明，听源性惊厥发作导致惊厥鼠上丘特定部位神经元内ＦＯＳ表达增加，说明这些神经元在惊厥发作时是兴奋的。本文讨论了这些神经元在惊厥发作状态下可能起的作用。
Objective To observe the distribution of FOS immunoreactive neurons in the superior colliculus during seizures in genetically controlled (ACI) -induced seizure-prone rats. Methods Experimental animals were divided into 4 groups. PS group: seizure rats with acute seizures induced by bells (106dB, 10 ~ 20kHz, 60s); PN group: seizure rats without seizures; WS group: normal bell-stimulated rats; WN group: Normal mouse. 5 in each group. PS and WS group survived 2h after bells stimulated. Results ① Only typical FOS-like immunoreactive neurons were found in the upper hill of PS rats, and they were only distributed in the IV, VI and Ⅶ layers. ② In the fourth, sixth and seventh layers of the superior colliculus in the PS rat, the majority of FOS-like immunoreactive neurons were found in the caudal segment. Conclusion The results of this study indicate that the onset of seizures in the febrile seizures leads to the increase of FOS expression in the neurons of certain parts of the upper extremity of convulsion mice, indicating that these neurons are excited during the seizure. This article discusses the possible role of these neurons in seizures.