论文部分内容阅读
目的:观察子宫肌瘤患者术前采用醋酸亮丙瑞林预处理的疗效。方法:70例子宫肌瘤患者随机分为观察组和对照组,每组35例。对照组行腹腔镜下子宫肌瘤剔除术。观察组先给予醋酸亮丙瑞林3.75 mg皮下注射,每月1次,连续治疗3个月后,再进行腹腔镜下子宫肌瘤剔除术。比较观察组患者使用醋酸亮丙瑞林前后的血清激素水平、月经情况、肌瘤及子宫体积变化,比较两组患者的术中术后情况、子宫肌瘤复发率。结果:观察组患者给予醋酸亮丙瑞林后,黄体生成素(LH)、卵泡刺激素(FSH)、血清雌二醇(E2)水平均明显低于用药前(P<0.05),月经量、子宫体积、肌瘤体积明显小于用药前(P<0.05)。观察组患者的术中出血量、盆腔引流量明显低于对照组(P<0.05),下床活动时间、住院时间明显短于对照组(P<0.05)。结论:子宫肌瘤患者术前给予醋酸亮丙瑞林预处理,可明显降低患者的血清激素水平,缩小肌瘤体积,有利于开展子宫肌瘤剔除术,术中创伤较小,有利于患者的预后。
Objective: To observe the efficacy of leuprolide acetate pretreatment in patients with uterine fibroids. Methods: 70 cases of uterine fibroids were randomly divided into observation group and control group, 35 cases in each group. The control group underwent laparoscopic myomectomy. Observation group was given leuprolide 3.75 mg subcutaneously once a month for 3 months, and then laparoscopic myomectomy. The changes of serum hormone level, menstrual status, fibroids and uterine volume before and after administration of leuprolide acetate in the observation group were compared. The intraoperative and postoperative conditions and the recurrence rate of uterine fibroids were compared between the two groups. Results: After administration of leuprolide acetate, the levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and serum estradiol (E2) in observation group were significantly lower than those before treatment (P <0.05) Uterine volume, fibroids volume was significantly less than before treatment (P <0.05). The blood loss and pelvic drainage volume in the observation group were significantly lower than those in the control group (P <0.05). The time of bed ambulation and hospital stay were significantly shorter than those in the control group (P <0.05). Conclusion: Pretreatment with leuprolide preoperatively in patients with uterine fibroids can significantly reduce the level of serum hormone in patients, reduce the size of fibroids, is conducive to the myomectomy, less trauma during surgery, which is good for patients Prognosis.