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先天性心脏病是儿童最常见先天性畸形,也是导致儿童心力衰竭的常见原因之一.目前临床上对于儿童心力衰竭的诊断主要依靠病史、症状及体征,主观性较强,缺乏及时、简便的客观指标,容易漏诊.脑钠肽及氨基末端脑钠肽前体是主要由心室肌细胞合成并分泌的多肽类物质,在反映心室收缩、舒张功能及前后负荷方面具有良好的敏感性,在各种心血管疾病研究中应用广泛.近年来不少研究表明,二者血浆浓度也可用于指导先天性心脏病患儿围手术期手术治疗及预后评估.该文就脑钠肽及氨基末端脑钠肽前体在儿童先天性心脏病及合并心力衰竭、围手术期方面应用价值作一综述.“,”Congenital heart disease (CHD) is the most common congenital malformation and also one of the common causes of heart failure in children.At present,the clinical diagnosis of heart failure in children mainly depends on the medical history,symptoms and signs,with strong subjectivity and lack of timely and simple objective criteria,which are easy to be missed.Brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-ProBNP) are polypeptides synthesized and secreted by ventricular myocytes,which have good sensitivity to reflect ventricular systolic,diastolic function and pre-and post-load.They have been widely used in various cardiovascular diseases.In recent years,many studies have shown that the plasma concentration of the two can be used to guide perioperative surgical treatment and evaluate the perioperative prognosis risk of children with CHD.This article reviews the application of BNP and NT-ProBNP in children with CHD with heart failure,especially during perioperative period.