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目的检测肝细胞癌(HCC)患者血清血管内皮生长因子(VEGF)含量并分析与临床分期的相关性。方法用ELISA法检测30例健康对照者和146例HCC患者血清VEGF含量,分析VEGF对HCC的诊断价值和临床分期的关系。结果HCC组VEGF水平显著高于健康对照组VEGF水平(P<0.01)。HCC患者VEGF水平与肿瘤大小呈正相关(P<0.01),HCC术后转移和复发患者血清VEGF水平明照升高(P<0.05),TNMⅢ、Ⅳ期患者血清VECF水平也明显高于Ⅰ、Ⅱ期患者(P<0.01)。结论血清VEGF测定可作为诊断HCC和临床分期的重要指标。
Objective To detect the serum levels of vascular endothelial growth factor (VEGF) in patients with hepatocellular carcinoma (HCC) and analyze the correlation with clinical stage. Methods The serum levels of VEGF in 30 healthy controls and 146 HCC patients were detected by ELISA. The relationship between the diagnostic value of HCC and clinical stage was analyzed. Results The VEGF level in HCC group was significantly higher than that in healthy control group (P <0.01). The level of VEGF in HCC patients was positively correlated with the tumor size (P <0.01), and the levels of serum VEGF in patients with HCC metastases and recurrences were significantly increased (P <0.05). The serum levels of VECF in patients with TNM Ⅲ and Ⅳ were also significantly higher than those in patients with stage Ⅰ and Ⅱ Patients (P <0.01). Conclusion Serum VEGF can be used as an important index in the diagnosis of HCC and clinical stage.