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DNA损伤后细胞周期停止 ,部分是由于 p53抑癌基因在转录水平上激活 P2 1WAF1的结果 ,可见 P2 1WAF1和 p53基因在维持放疗或化疗损伤 DNA后控制细胞周期是重要的因素。作者观察 P2 1WAF1和 p53在决定胰腺癌病人接受放疗或 (和 )化疗后结局的作用。应用免疫组化方法测定 90例胰腺
The cell cycle arrest after DNA damage is partly due to the activation of P2 1WAF1 at the transcriptional level of the p53 tumor suppressor gene. This shows that P2 1WAF1 and p53 genes are important factors in controlling cell cycle after maintaining radiotherapy or chemotherapy DNA damage. The authors examined the role of P2 1WAF1 and p53 in determining the outcome of patients with pancreatic cancer after radiotherapy or (and) chemotherapy. Immunohistochemical method for determination of 90 cases of pancreas