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我們制备了两种油溶陸三价锑剂,三(十二硫醇)锑及三(α-萘乙硫醇)锑。經对感染日本血吸虫病的动物疗效試驗,証明有作用,其毒性以三(α-萘乙硫醇)銻为低。在制造过程中,我們改进了十二硫醇、α-萘乙硫醇、三(十二硫醇)锑及三(α-萘乙硫醇)锑的制法,同时提高了它們的純度。我們得到的三(十二硫醇)锑熔点为45—46℃(文献为38—40℃);三(α-萘乙硫醇)銻的熔点为69—70℃(文献[6]为油狀或蜡狀固体)。
We have prepared two oil-soluble hexavalent antimony agents, tris (dodecyl mercaptan) antimony and tris (α-naphthylethanethiol) antimony. The efficacy test on animals infected with schistosomiasis japonica proved to be effective with tris (α-naphthyl ethanethiol) antimony as low. In the manufacturing process, we improved the preparation of dodecanethiol, α-naphthyl ethanethiol, tris (dodecyl mercaptan) antimony and tris (α-naphthylethanethiol) antimony while increasing their purity. The melting point of tris (dodecyl mercaptide) antimony is 45-46 ° C (literature 38-40 ° C); tris (α-naphthylethanethiol) antimony has a melting point of 69-70 ° C (Reference [6] Like or waxy solid).