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目的:探讨胰岛素加用格列美脲治疗单用胰岛素效果不佳2型糖尿病的疗效。方法:对2010年1月-2011年12月在某院就诊的单用胰岛素疗效不佳的糖尿病患者162例,随机分为2组:观察组82例,维持患者原治疗方案,并在每天早餐前服用格列美脲1~2 mg;对照组80例,维持患者原治疗方案,并于每天早晚各增加皮下注射胰岛素0.5~1U;并根据血糖情况随时调整用药,8周后采静脉血测空腹血糖和餐后2 h血糖和糖化血红蛋白。结果:2组治疗方案均可使患者的空腹血糖、餐后2 h血糖和糖化血红蛋白水平均比治疗前下降,但以观察组效果为佳,且不良反应少。结论:单用胰岛素治疗的2型糖尿病患者血糖控制不佳时,加用格列美脲后可显著改善血糖控制水平。
Objective: To investigate the efficacy of insulin plus glimepiride in the treatment of type 2 diabetes mellitus with insulin alone. Methods: A total of 162 diabetic patients with poor curative effect of insulin in a hospital from January 2010 to December 2011 were randomly divided into two groups: observation group (n = 82), maintenance of the original treatment plan and daily breakfast Before taking glimepiride 1 ~ 2 mg; 80 cases of the control group to maintain the patient’s original treatment programs, and in the morning and evening each subcutaneous injection of insulin 0.5 ~ 1U; and adjusted according to blood glucose medication at any time, 8 weeks after the detection of fasting blood glucose And 2 h postprandial blood glucose and HbA1c. Results: The fasting blood glucose, postprandial 2-hour postprandial blood glucose and glycosylated hemoglobin in both groups were lower than those before treatment, but the effect in the observation group was better with fewer adverse reactions. CONCLUSIONS: When glycemic control is not adequate in type 2 diabetic patients treated with insulin alone, glycemic control significantly improves glycemic control.