福辛普利(Fosinopril)是一种带磷酰基的前体药物,口服给药后,迅速水解成为有活性的ACEI——福辛普利拉(Fosinoprilat)。福辛普利不同于其它ACEI,它有一种代偿性双重消除途径,由肝和肾双重消除,当病人伴有肾功能减退时,则增加肝脏对福辛普利拉的消除。同样,当病人伴有肝功能减退时,则肾脏对福辛普利的消除增加。由于福辛普利 Fosinopril, a prodrug with phosphoryl, rapidly hydrolyzes to the active ACEI after oral administration of Fosinoprilat. Fosinopril, unlike other ACEIs, has a compensatory double-elimination route that is double-eliminated by the liver and kidneys and increases the liver’s elimination of fosapril when the patient is accompanied by a drop in kidney function. Similarly, when patients with liver dysfunction, then the elimination of fosinopril in the kidneys increased. Thanks to fosinopril