目的研究发热对豚鼠胆汁成分及胆石形成的影响．方法将豚鼠６０只分为致石饲料组和普通饲料组，再将每组分为发热组和对照组．皮下注射煮沸脱脂牛奶１ｍｇ／ｋｇ使发热组动物发热，每周１次，共４次．４５ｄ后将６０只豚鼠全部处死，其中发热组在处死前３６ｈ皮下注射松节油１ｍｌ／ｋｇ，使其在处死前处于发热状态．检查胆囊并取胆汁进行分析．结果致石饲料发热组结石发生率最高，为４００％，而致石饲料不发热组为１３３％（Ｐ＜００１）．发热组胆汁总蛋白（２５ｇ／Ｌ±１９ｇ／Ｌｖｓ１０ｇ／Ｌ±０９ｇ／Ｌ，Ａ２ｖｓＡ１）及胆红素浓度（７４３μｍｏｌ／Ｌ±６２６μｍｏｌ／Ｌｖｓ１２３μｍｏｌ／Ｌ±５５μｍｏｌ／Ｌ，Ｐ＜００５）较对照组明显升高．结论发热对豚鼠胆汁成分的影响在胆石形成中具有重要作用． Objective To study the effects of fever on bile composition and gallstone formation in guinea pigs. Methods 60 guinea pigs were divided into stone-fed group and normal feed group, and each group was divided into fever group and control group. Subcutaneous injection of skim milk 1mg / kg to fever group animals, 1 week, a total of 4 times. Forty-five guinea pigs were sacrificed after 45 days, in which the febrile group was subcutaneously injected with turpentine 1 ml / kg 36h prior to sacrifice, which was in a state of fever before death. Check the gallbladder and take bile for analysis. Results The incidence of stones in the stone-fed fever group was the highest (400%), while it was 133% (13.0%) in the stone-fed non-fever group (P00101). In fever group, total bile protein (2.5 ng / L ± 19 g / L vs 1.0 g / L ± 0.9 g / L, A2vsA1) and bilirubin concentration (743 μmol / L ± 626 μmol / Lvs123 μmol / L ± 55μmol / L, P <005) than the control group was significantly higher. Conclusion The effect of fever on the biliary component of guinea pigs plays an important role in gallstone formation.