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Ｎ－乙酰半胱氨酸（ＮＡＣ）是体内游离巯基的组成部分，既可补充体内谷胱甘肽，又具有清除自由基、保护细胞的作用。本实验观察了ＮＡＣ在大鼠肠系膜上动脉夹闭（ＳＭＡＯ）造成的肠缺血再灌损伤和继发性肺损伤时对肠、肺的保护效应。ＳＭＡＯ４５ｍｉｎ松夹，于松夫前、后５分钟尾静脉注射ＮＡＣ（５０ｍｇ／ｋｇ），测定松夹后２、４、６ｈ肠、肺组织总巯基（ＴＳＨ）和游离巯基（ＮＰＳＨ）以及丙二醛（Ｍ ＤＡ）和髓过氧化物酶（Ｍ ＰＯ）的改变。结果显示静注ＮＡＣ后可明显增加肠肺ＮＰＳＮ．降低肠、肺ＭＤＡ和ＭＰＯ，说明ＮＡＣ对缺血再灌注引起的肠、肺损伤有防治效应。
N-acetylcysteine (NAC) is an integral part of the body free thiol, both glutathione supplement, but also has the role of free radicals to protect cells. This experiment observed the protective effects of NAC on intestine and lung during intestinal ischemia-reperfusion injury and secondary lung injury induced by SMAO in rats. SMAO45min pine needles, 5 minutes after Naoshuo injection, NAC (50mg / kg) was injected through the caudal vein to measure the contents of TSH, NPSH and MDA M DA) and myeloperoxidase (M PO). The results showed that intravenous NAC can significantly increase intestinal NPSN. Reduce intestinal MDA and MPO MDA, indicating NAC on ischemia-reperfusion-induced intestinal and lung injury prevention and treatment effects.