移植肾功能延迟恢复(DGF)是肾移植术后的一种常见并发症,临床上表现为少尿或无尿、血肌酐持续不降或缓慢下降,能增加急性排斥反应发生的危险性,并缩短移植物长期存活时间。最近几年DGF的发生率仍保持在30%左右。低温保存后移植肾局部缺血和缺血-再灌注损伤(ischemia-repefusion injury)激活了一系列反应,使肾持续受损,在DGF发展中起主导作用。局部缺血-再灌注损伤病理生理机制的 Delayed graft transplant (DGF) is a common complication after renal transplantation. The clinical manifestations are oliguria or anuria. The continuous or undetectable serum creatinine can increase the risk of acute rejection. Shorten the graft long-term survival time. The incidence of DGF in recent years remains at about 30%. After cryopreservation, a series of responses to renal ischemia and reperfusion injury activate a series of persistent renal damage and play a leading role in the development of DGF. Pathophysiological mechanism of ischemia-reperfusion injury