论文部分内容阅读
利用高氟化碳(PFC)进行液体通气是治疗重症呼吸衰竭的新兴技术。PFC是一种无色秀明、无味的惰性气体,表面张力低,对呼吸气体的溶解度高,这样,就能在较低的吸入压反吸入氧浓度下进行适当的气体交换,另外,由于肺膨胀均匀,经肺部投药更具有优势,可用于治疗呼吸窘迫综合征(RDS)、持续肺动脉高压(PPH)、胎粪吸入综合征(MAS)及重症肺炎等多种肺部疾患。初步结果表明,液体通气能增加肺的顺应性,改善通气/血流比值,具有良好的应用前景,但在广泛运用于临床之前,仍须进一步明确其安全性及有效性。本文综述了液体通气的历史、液体性质、理论基础、装置与方法及应用现状。
Ventilation using highly fluorinated carbon (PFC) is an emerging technology for the treatment of severe respiratory failure. PFC is a colorless, odorless, inert gas with low surface tension and high solubility in respiratory gases, allowing for proper gas exchange at low inhalation pressure and reverse osmotic oxygen concentration. In addition, due to lung expansion Uniform, pulmonary delivery is more advantageous and can be used to treat various lung diseases such as respiratory distress syndrome (RDS), persistent pulmonary hypertension (PPH), meconium aspiration syndrome (MAS) and severe pneumonia. Preliminary results show that liquid ventilation can increase lung compliance and improve ventilation / blood flow ratio, has good prospects for application, but in the widely used in clinical, still need to further clarify its safety and effectiveness. This paper summarizes the history of liquid aeration, the nature of liquids, the theoretical basis, devices and methods, and current status of applications.