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目的研究玉米须水提物(AECS)对自发性高血压大鼠的降压作用和机制。方法自发性高血压大鼠随机分为模型组、AECS 5和15 g·kg~(-1)组,WKY大鼠作为正常对照组,各组灌胃给药,连续25 d。每5 d监测鼠尾血压变化,第25天取血浆测定总抗氧化能力、谷胱甘肽和血管紧张素Ⅱ水平。结果与WKY组比较,模型组大鼠收缩压和舒张压增高,血浆总抗氧化能力和谷胱甘肽水平降低,血管紧张素Ⅱ水平增高;与模型组比较,AECS 5和15 g·kg~(-1)组自第5天开始收缩压和舒张压均下降,持续至25d,血浆总抗氧化能力和谷胱甘肽水平增高,血管紧张素Ⅱ水平下降。结论玉米须水提物对自发性高血压大鼠有降压作用,机制与降低血管紧张素Ⅱ水平和抗氧化应激有关。
Objective To study the antihypertensive effect and mechanism of corn aqueous extract (AECS) on spontaneously hypertensive rats. Methods Spontaneous hypertensive rats were randomly divided into model group, AECS 5 and 15 g · kg -1 groups, WKY rats as normal control group. Each group was given gavage for 25 consecutive days. Tail blood pressure was monitored every 5 days, and the total antioxidant capacity, glutathione and angiotensin II levels were measured on the 25th day. Results Compared with the WKY group, the systolic and diastolic blood pressure increased, the total plasma antioxidant capacity and glutathione level decreased and the level of angiotensin Ⅱ increased. Compared with the model group, AECS 5 and 15 g · kg ~ (-1) group began to reduce systolic and diastolic blood pressure from day 5 onwards. After 25 days, the total plasma antioxidant capacity and glutathione level increased and the level of angiotensin Ⅱ decreased. Conclusion The aqueous extracts from corn needles have antihypertensive effects on spontaneously hypertensive rats. The mechanism is related to decreasing the level of angiotensin Ⅱ and anti-oxidative stress.