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目的:分析伴冠心病牙周炎患者的牙周临床检查指标及血清肿瘤坏死因子-α(TNF-α)水平,为牙周炎与冠心病关系的研究提供实验依据。方法:44例伴冠心病牙周炎患者、48例慢性牙周炎患者和45例健康对照进入此项研究。对入选对象进行全面牙周检查,检测血清TNF-α水平。结果:3组对象的血清TNF-α水平、平均牙周探诊深度、平均牙龈附着丧失、平均龈沟出血指数均差异有统计学意义(F=49.424,274.630,1051.612,303.041,P<0.001),伴冠心病牙周炎组的各项观测指标均高于慢性牙周炎组(P<0.05)。结论:冠心病可能会加重牙周局部炎症。
Objective: To analyze the clinical periodontal examination index and serum level of tumor necrosis factor-α (TNF-α) in patients with periodontitis with coronary heart disease and to provide experimental basis for the study of the relationship between periodontitis and coronary heart disease. METHODS: Forty-four patients with periodontitis with coronary heart disease, 48 patients with chronic periodontitis and 45 healthy controls were enrolled in this study. A comprehensive periodontal examination of the selected subjects, serum TNF-α levels. Results: The serum levels of TNF-α, average periodontal exploration depth, average gingival attachment loss and mean sulcus bleeding index of the three groups were significantly different (F = 49.424,274.630,1051.612,303.041, P <0.001) , With coronary heart disease group of periodontal observation indicators were higher than the chronic periodontitis group (P <0.05). Conclusion: Coronary heart disease may aggravate periodontal inflammation.