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乙烷是活性氧自由基作用生物膜磷脂结构中的不饱和脂肪酸所生成的微量挥发性碳氢化合物,可以认为是比较生理地反映体内脂质过氧化的一个指标。吸烟者出现不同程度的慢阻肺(COPD),认为是由于烟草烟雾导致气管、支气管乃至于肺气肿有关。本文利用气相色谱法检测了43人呼出气中乙烷含量,分为未吸烟组(17人),吸烟组(16人),吸烟伴COPD组(10人)。对比观察其吸烟者脂质过氧化损伤情况。结果发现未吸烟组呼出气中乙烷含量为4.246±0.496ppm/kg/min(3.19～5.22ppm/kg/min);吸烟组呼出气中乙烷含量21.573±9.478ppm/kg/min(11.34～26.82ppm/kg/min);明显高于未吸烟组(P<0.01);吸烟伴COPD组呼出气乙烷含量明显高于无并发症的吸烟组,为37.524±7.765ppm/kg/min(31.36～45.96)(P<0.001)。上述结果证明,脂质过氧化可能参与了吸烟者肺损害的发生和发展。
Ethane is a reactive oxygen species free radicals biofilm phospholipid structure of unsaturated fatty acids generated by the micro-volatile hydrocarbons, can be regarded as a more physiological reflection of lipid peroxidation in an indicator. Smokers appear to varying degrees of chronic obstructive pulmonary disease (COPD), that is due to tobacco smoke lead to the trachea, bronchus and even emphysema related. In this paper, gas chromatography was used to detect the content of ethane in the exhaled breath of 43 people, divided into non-smoking group (17), smoking group (16) and smoking with COPD group (10). Comparative observation of their smokers lipid peroxidation damage. As a result, it was found that the ethane content in exhaled breath was 4.246 ± 0.496ppm / kg / min (3.19-5.22ppm / kg / min) in non-smoker group and 21.573 ± 9.478ppm / kg / min (11.34 ~ 26.82ppm / kg / min) was significantly higher than that of non-smoking group (P <0.01). The exhaled ethane and ethane in smoking group was significantly higher than that in non-smoking group (37.524 ± 7.765ppm / kg / min ~ 45.96) (P <0.001). These results demonstrate that lipid peroxidation may be involved in the occurrence and development of lung injury in smokers.