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目的探讨颈动脉粥样硬化(CAS)斑块及血脂、血糖(BG)、纤维蛋白原(Fbg)水平与脑梗死的关系。方法对2007年11月-2008年12月入院的91例脑梗死患者,应用彩色多普勒检测其颈动脉内-中膜厚度(IMT)、斑块数和性状,同时检测血脂、血糖、纤维蛋白原水平,并与正常对照组比较。结果①与正常对照组比较,脑梗死组IMT明显增厚、CAS斑块检出率、软斑百分比明显增高(P<0.05)。②血清总胆固醇(TC)、低密度脂蛋白(LDL)、BG及Fbg水平脑梗死组明显高于正常对照组(P<0.05);脑梗死有斑块亚组明显高于无斑块亚组(P<0.05)。③脑梗死组IMT与TC、LDL、BG、Fbg水平呈正相关(r分别为0.32、0.34、0.30、0.36,P<0.05)。结论脑梗死患者IMT增厚,CAS斑块及软斑发生率高。BG、TC、LDL及Fbg水平增高是脑梗死及CAS斑块发生的危险因素。
Objective To investigate the relationship between carotid atherosclerosis (CAS) plaque, blood lipid, blood glucose (BG), fibrinogen (Fbg) and cerebral infarction. Methods Totally 91 patients with cerebral infarction who were hospitalized from November 2007 to December 2008 were examined for carotid artery IMT, plaque number and trait by color Doppler. Blood lipids, blood glucose, Protein level, and compared with the normal control group. Results ① Compared with the normal control group, IMT was significantly thicker in cerebral infarction group, and the detection rate of CAS plaque and the percentage of soft spot were significantly higher (P <0.05). ② The levels of total cholesterol (TC), low density lipoprotein (LDL), BG and Fbg in cerebral infarction group were significantly higher than those in normal control group (P <0.05); the plaque subgroups in cerebral infarction were significantly higher than those in non-plaque subgroup (P <0.05). ③ IMT was positively correlated with TC, LDL, BG and Fbg in cerebral infarction group (r = 0.32,0.34,0.30,0.36, P <0.05). Conclusions IMT is thickened in patients with cerebral infarction, and the incidence of CAS plaques and soft spots is high. The levels of BG, TC, LDL and Fbg are risk factors of cerebral infarction and CAS plaque.