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应用头颅CT,对60例重度窒息儿静注苯巴比妥预防颅内病变及惊厥进行对照研究。用药组接受负荷量的平均年龄为生后5.2±1.6小时,生后第4天的血清药物浓度为22.5±4.7mg/L。CT显示:用药组脑损伤的发病率为66.7％,对照组为90％,两组之间差异有显著性意义(x~2=4.81,P<0.05)。用药组静注苯巴比妥后,仅1例发生惊厥,对照组的惊厥持续时间显著延长(t=6.34,P<0.05)。研究证实苯巴比妥可显著降低窒息后脑损伤的发病率,并能预防和控制惊厥的发生。
Application of head CT, 60 cases of severe asphyxia infantile phenobarbital intracranial lesions and convulsions control study. The average age of receiving drug load group was 5.2 ± 1.6 hours after birth, and the serum drug concentration was 22.5 ± 4.7 mg / L on the fourth day after birth. CT showed that the incidence of brain injury was 66.7% in the treatment group and 90% in the control group, with significant difference between the two groups (x ~ 2 = 4.81, P <0.05). Only 1 patient developed convulsion after treatment with phenobarbital, while the duration of convulsion in the control group was significantly prolonged (t = 6.34, P <0.05). Study confirmed that phenobarbital can significantly reduce the incidence of asphyxia brain injury, and can prevent and control the occurrence of convulsions.