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目的比较中晚期鼻咽癌患者顺铂(DDP)同期放化疗与单纯放疗的疗效。方法 124例中晚期鼻咽癌患者,随机分为实验组(51例)和对照组(73例)。实验组进行单药DDP同期放化疗,对照组行单纯放疗,比较两组的临床疗效。结果两组总有效率比较差异无统计学意义(P>0.05)。对照组2、3年无病生存率分别为73.97%、67.12%;实验组2、3年无病生存率分别为88.24%、84.31%。实验组2、3年无病生存率均高于对照组,两组2年无病生存率比较差异无统计学意义(P>0.05);两组3年无病生存率比较差异有统计学意义(P<0.05)。结论中晚期鼻咽癌患者行DDP同期放化疗的疗效高于单纯放疗,值得临床推广应用。
Objective To compare the efficacy of cisplatin (DDP) concurrent chemoradiotherapy with radiotherapy alone in patients with advanced nasopharyngeal carcinoma. Methods 124 patients with advanced nasopharyngeal carcinoma were randomly divided into experimental group (n = 51) and control group (n = 73). The experimental group received single-drug concurrent DDP radiotherapy and chemotherapy, and the control group received simple radiotherapy. The clinical efficacy of the two groups was compared. Results There was no significant difference in total effective rate between the two groups (P> 0.05). The 2-year and 3-year disease-free survival rates in the control group were 73.97% and 67.12%, respectively. The 2-year and 3-year disease-free survival rates in the experimental group were 88.24% and 84.31%, respectively. The 2-year and 3-year disease-free survival rates in the experimental group were significantly higher than those in the control group. There was no significant difference in the 2-year disease-free survival rate between the two groups (P> 0.05). There was significant difference in the 3-year disease- (P <0.05). Conclusions Advanced radiotherapy and chemotherapy for advanced nasopharyngeal carcinoma patients with DDP is more effective than radiotherapy alone and is worthy of clinical application.