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研究呼吸道感染标本中铜绿假单胞菌的血清型和12种抗生素的体外抗菌活性．方法：标本获得纯培养后应用VITEK-AMS微生物自动分析仪鉴定细菌，用PA20系列血清分型，用K-B纸片法按NCCLS规定的标准进行敏感试验．结果：引起呼吸道感染的58株绿脓杆菌血清分型率为94．83％，主要以PA6，PA2，PA4型为主．58株菌对12种抗生素的平均耐药率为47．6％，对舒普深、奥复星、泰能的耐药率均在12．1％以下，而对氧哌嗪青霉素、凯福隆、特美汀的耐药率在62．4％以上，5重以上耐药菌占70．7％．58株菌中产β-内酰胺酶的菌株占63．8％，产酶菌对舒普深、奥复星、泰能的耐药率均在18．9％以下，而对罗氏芬、氧哌嗪青霉素、凯福隆、特美汀的耐药率在68．4％以上，5重以上耐药菌占83．8％．结论：由铜绿假单胞菌引起的呼吸道感染在未获得细菌药敏结果以前，应最好选合酶抑制剂抗生素舒普深或奥复星配以庆大霉素或丁胺卡那治疗；对产酶菌应首选舒普深、奥复星或泰能治疗；对非产酶菌可选用第3代头孢菌素先锋必或复达欣并辅以庆大霉素、妥布霉素或丁胺卡那等一般抗生素治疗．
To study the in vitro antibacterial activity of serotypes of Pseudomonas aeruginosa and 12 kinds of antibiotics in respiratory tract specimens. Methods: The samples were purely cultured and identified by VITEK-AMS automatic analyzer. PA20 serotypes were used to classify the bacteria. K-B method was used to conduct the sensitivity test according to the standard of NCCLS. Results: The serotypes of 58 strains of P. aeruginosa causing respiratory tract infections were 94.83%, mainly PA6, PA2 and PA4. The average resistance rate of 58 strains to 12 kinds of antibiotics was 47.6%, and the resistance rate to shuopunshen, auspicious fox, tainung was below 12.1% Long, timentin resistant rate was 62.4%, 5 or more resistant bacteria accounted for 70.7%. Among 58 strains, β-lactamase producing strains accounted for 63.8%. The resistance rates of the producing strains to schuh-shen, auspicious-fang and thantan were below 18.9% The rates of resistance to phenazine penicillin, kaifulong and timentin were above 68.4%, 83.8% of which were over 5 resistant. CONCLUSIONS: Before respiratory infections caused by Pseudomonas aeruginosa can not get bacterial susceptibility results, it is advisable to select the enzyme inhibitor antibiotics Shu Pushen or Orfloxacin together with gentamicin or amikacin. The enzyme-producing bacteria should be preferred Schipper deep, Austria Fuxing or Thai can treat; non-producing bacteria can choose the third generation cephalosporins Pioneer or Fu Daxin supplemented with gentamicin, tobramycin or Amikacin and other general antibiotic treatment.