组蛋白修饰是一种重要的表观遗传学现象,对基因表达调控发挥着至关重要的作用。一般认为糖尿病是一种由环境因素、遗传因素及免疫因素等共同作用的代谢性疾病,其发病机制主要与胰岛素抵抗、胰岛素分泌不足及免疫炎症等密切相关。目前,糖尿病的发病机制尚未完全清楚,治疗中也有一定局限性。但有研究表明组蛋白修饰与糖尿病的发病有密切关系。 Histone modification is an important epigenetic phenomenon that plays a crucial role in the regulation of gene expression. It is generally believed that diabetes is a metabolic disease that is caused by environmental factors, genetic factors and immune factors, and its pathogenesis is mainly related to insulin resistance, insufficient insulin secretion and immune inflammation. At present, the pathogenesis of diabetes is not yet fully understood, there are some limitations in the treatment. However, studies have shown that histone modification and the incidence of diabetes are closely related.