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目的探讨N-端脑利钠肽前体(NT-proB NP)对子痫前期孕妇围产儿的评价效果。方法选取诊治的轻度子痫前期孕妇120例、重度子痫前期孕妇120例、正常妊娠孕妇120例于门诊第1天和终止妊娠前行NT-proB NP检测,分析围产儿妊娠结局。结果轻度子痫前期与重度子痫前期NT-proB NP、舒张压、收缩压干预前后检测值对比差异有统计学意义(P<0.05);随着子痫前期病情加重,NT-proB N、舒张压、收缩压增高(P<0.05),胎儿宫内发育迟缓、早产儿、无应激实验阴性、低体重儿例数增多(P<0.05)。轻度子痫前期同正常妊娠相比,新生儿体重、羊水量减少(P<0.05);重度子痫前期同正常妊娠、轻度子痫前期相比,新生儿死亡人数增加、体重降低、S/D增高、Apgar评分下降、羊水量减少(P<0.05)。随着NT-proB NP水平升高,围产儿体重、Apgar评分、羊水量减低,S/D升高(P<0.05),胎儿宫内发育迟缓、早产儿、无应激实验阴性、低体重儿发生率增多(P<0.05)。结论 NT-proB NP可做为子痫前期严重程度的判断指标;母体子痫前期病情进展程度是影响围生儿预后的重要因素,NT-proB NP可用于评价围生儿预后。
Objective To evaluate the effect of N-terminal pro-brain natriuretic peptide (NT-proB NP) on perinatal pregnancy in preeclampsia. Methods 120 cases of mild preeclampsia, 120 cases of severe preeclampsia and 120 cases of normal pregnant women were enrolled in this study. NT-proBNP assay was performed on the first day of outpatient and termination of pregnancy, and the outcome of perinatal pregnancy was analyzed. Results The difference of NT-proB NP, diastolic blood pressure and systolic blood pressure before and after intervention in mild preeclampsia and severe preeclampsia was statistically significant (P <0.05). With the aggravation of preeclampsia, NT-proB N, Diastolic blood pressure, systolic blood pressure increased (P <0.05), intrauterine growth retardation, premature children, no stress test was negative, the number of cases of low birth weight increased (P <0.05). In mild preeclampsia compared with normal pregnancy, neonatal body weight and amniotic fluid volume decreased (P <0.05); severe preeclampsia compared with normal pregnancy, mild preeclampsia, newborns increased the number of deaths, weight loss, S / D increased, Apgar score decreased, amniotic fluid decreased (P <0.05). Perinatal weight, Apgar score, amniotic fluid volume, S / D increased (P <0.05), fetal intrauterine growth retardation, premature infant, non-stress test negative, low birth weight The incidence increased (P <0.05). Conclusion NT-proB NP can be used as an indicator of the severity of preeclampsia. The extent of progression of maternal preeclampsia is an important factor affecting the prognosis of perinatal children. NT-proB NP can be used to evaluate the prognosis of perinatal children.