目的观察乙型肝炎肝内血管阻塞性病变与肝纤维化之间的关系．方法对１０７９例乙型肝炎的肝活检标本静脉阻塞作了观察．并对肝组织中网状、胶原、弹力纤维作组织化学及ＦＮ、ＬＮ作免疫组化染色（ＡＢＣ法）．结果肝纤维化指数随肝内血管阻塞的轻（２９４±１５６）、中（５０８±１３０）、重度（６６３±１９７）而上升．在血管阻塞轻度组６１％无纤维带形成，其较窄占３９％，而中度组较窄占５１％，较宽占４９％（Ｐ＜００１），重度组较窄仅７８％，而较宽则占９２２％（Ｐ＜００１）．其Ｆｉ组织病理学有高度的区域性差异，且与被阻塞的静脉相伴随；新形成的纤维带由毛细血管所构成；桥接性纤维化由新形成的小血管相连接；肝硬变的纤维带构成与血管损伤相一致．结论乙型肝炎肝纤维化及肝硬变由肝内静脉阻塞所致． Objective To observe the relationship between intrahepatic vascular occlusive disease and hepatic fibrosis in hepatitis B patients. Methods 1079 cases of hepatitis B liver biopsy specimens were observed obstruction. Histochemistry, FN and LN were used for immunohistochemical staining of the reticular, collagen and elastic fibers in the liver tissue (ABC method). Results The liver fibrosis index increased with the severity of intrahepatic vascular occlusion (294 ± 156), middle (508 ± 130) and severe (663 ± 197). The lesser degree of vascular occlusion was found in 61% of the non-fibrous bands, which was 39% narrower, while the moderate group was 51% narrower and 49% wider (P <001), while the severe group was 7% narrower. 8%, while the wider accounted for 92  2% (P <0  01). Fi histopathology has a highly regional difference and is accompanied by obstructed veins; the newly formed fibrous band is composed of capillaries; bridging fibrosis is connected by newly formed small vessels; and the fibers of cirrhosis Belt composition and vascular injury consistent. Conclusion Hepatic fibrosis and cirrhosis caused by intrahepatic venous obstruction.