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Objective:To study cell cycle retardation.apoptosis and the expression of antioncogene p57kip2 by radioactive rays in nasophageal carcinoma cells.Methods:Cell cycle retardation.apoptosis and cell suwival rate induced by radioactive rays were tested by the methods of flow cytometry and MTT method.The expression of antioncogene p57kip2 was detected bv immunohislochemistry and Weste blot.Results:After irradiation,G1 phase had no obvious retardation,S phase showed transient delay.There was a positive correlation between irradiation dosage and retardation strength in G2/M phase(P＜0.01).Peak value appeared at 24 h after 12 Gy irradiation,then decreased.There was a positive correlation between apoptosis incidence and irradiation dosage or after-irradiation time extention(P＜0.01).There was a negative correlation between cell survival rate and irradiation dosage or apoptosis incidence(P＜0.01).The expression of p57 kjP2 protein was up-regulated along with the prolongation of time and dosage after irradiation(P＜0.01).Conclusion:G2/M phase arrest,apoptosis and the up-regulation of the expression of p57kiP2 protein all can reflect predic the radiosensitivity of nasopharyngeal carcinoma cells.