氨基醇具有一定的镇静生理活性,通常由氨基酮还原制得。β-或α-氨基酮经Al-Hg齐和电化学还原可得到相应的二氨基听呐醇,然而,此法操作不便,产率很低,又具有毒性。我们以甲醇为溶剂,用9种氨基酮盐酸盐1与15％的三氯化钛水溶液在碱性条件和Ar气保护下反应,得到相应的双分子还原产物——二氨基(口片)呐醇,并分离出dl-和meso-异构体。 Amino alcohols have some calming physiological activity, usually obtained by the reduction of aminoketone. However, this method is inconvenient to operate, with low yield and toxicity. We use methanol as solvent, with 9 kinds of aminoketal hydrochloride 1 and 15% aqueous solution of titanium trichloride under alkaline conditions and Ar gas reaction to give the corresponding bimolecular reduction products - diamino (tablets) Alcohol and isolated dl- and meso-isomers.