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目的观察神经节苷脂治疗新生儿缺血缺氧性脑病(HIE)的临床疗效。方法选取2013年7月—2015年7月南京鼓楼医院集团宿迁市人民医院收治的新生儿HIE患儿84例,采用随机数字表法分为对照组和观察组,每组42例。对照组患儿给予常规治疗,观察组患儿在常规治疗基础上给予神经节苷脂治疗。比较两组患儿临床疗效、临床症状恢复时间、治疗前后新生儿神经行为评分(NBNA)及血清神经元特异性烯醇酶(NSE)水平。结果观察组患儿临床疗效优于对照组(P<0.05)。观察组患儿意识障碍、惊厥、原始反射、肌张力恢复时间均短于对照组(P<0.05)。两组患儿治疗前NBNA及血清NSE水平比较,差异均无统计学意义(P>0.05);观察组患者治疗后NBNA高于对照组,血清NSE水平低于对照组(P<0.05)。结论神经节苷脂治疗新生儿HIE的临床疗效确切,可有效减轻患儿临床症状及神经系统功能损伤。
Objective To observe the clinical effect of ganglioside on neonatal hypoxic-ischemic encephalopathy (HIE). Methods Eighty-four neonates with HIE admitted to Nanjing Gulou Hospital Group from July 2013 to July 2015 were randomly divided into control group and observation group with 42 cases in each group. The control group of children given conventional treatment, the observation group of children given conventional treatment based on ganglioside treatment. The clinical efficacy, clinical symptom recovery time, neonatal neurobehavioral score (NBNA) and serum neuron specific enolase (NSE) levels were compared between the two groups. Results The clinical efficacy of observation group was better than that of control group (P <0.05). The disturbance of consciousness, convulsion, reflex and muscle tone in observation group were shorter than those in control group (P <0.05). The NBNA and serum NSE levels were not significantly different between the two groups before treatment (P> 0.05). The NBNA of the observation group was higher than that of the control group after treatment, and the serum NSE level was lower than that of the control group (P <0.05). Conclusion Ganglioside treatment of neonatal HIE clinical efficacy is exact, can effectively reduce the clinical symptoms and nervous system dysfunction in children.