目的和方法：本文通过一次性阻断兔冠脉左室支１５ｍｉｎ后再灌注复制在体心肌顿抑（ＭＳ）模型，动态观察心肌缺血前后红细胞变形指数（ｄｅｆｏｒｍａｂｉｌｉｔｙｉｎｄｅｘ，ＤＩ）、红细胞超氧化物歧化酶（ｓｕｐｅｒｏｘｉｄｅｄｉｓｍｕｔａｓｅ，ＳＯＤ）活力、红细胞ＡＴＰ、红细胞丙二醛（ＭＤＡ）含量和心功能参数（左室舒张末压、左室收缩压±ｄｐ／ｄｔｍａｘ）变化。结果：缺血末心功能下降最显著（Ｐ＜００１）；再灌注０５ｈ时ＭＤＡ明显升高，而ＤＩ、ＳＯＤ明显下降（Ｐ＜００１）。随继续再灌注上述指标逐渐恢复。各时点ＡＴＰ无明显变化。再灌注０５ｈ时红细胞ＭＤＡ与ＤＩ、ＳＯＤ均呈显著负相关（Ｐ＜００１），ＤＩ与＋ｄｐ／ｄｔｍａｘ正相关（Ｐ＜００５）。结论：ＭＳ早期红细胞变形性降低与暂时性氧化－抗氧化失衡有关；再灌注早期红细胞变形性降低可能参与ＭＳ早期发生机制 PURPOSE AND METHODS: In this study, the left ventricular branches of rabbit coronary artery were occluded for 15 min and then reperfused in MS model. The deformability index (DI), erythrocyte superoxide Superoxide dismutase (SOD) activity, erythrocyte ATP, red blood cell malondialdehyde (MDA) content and cardiac function parameters (left ventricular end-diastolic pressure, left ventricular systolic pressure ± dp / dtmax). Results: The decline of cardiac function was the most significant at the end of ischemia (P <001). At 05 h of reperfusion, MDA was significantly increased, while DI and SOD were significantly decreased (P <001). With the continued reperfusion of the above indicators gradually restored. ATP at any time did not change significantly. There was a significant negative correlation between MDA and DI and SOD (P <001) and DI and + dp / dtmax at 05 h after reperfusion (P <005). CONCLUSION: Decreased erythrocyte deformability in MS is associated with transient oxidative-anti-oxidative imbalance. Decreased erythrocyte deformability may be involved in the early pathogenesis of MS