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目的 探讨家兔心肌梗死急性期曲马多对心肌的保护作用。方法 2 5～ 3kg家兔 16只 ,随机分为 2组 ,对照组 (control) :单纯结扎冠状动脉左对角支 ;曲马多组 (tramadol) :于结扎前 10min静脉注射曲马多 10mg ,并于结扎后 3h等量补充。各组均行左股动脉穿刺监测平均动脉压 (MAP) ,并分别于给药及结扎前 (basic)、结扎后 3h、结扎后 6h抽取颈外静脉血 ,测血中一氧化氮 (NO)含量。结果 MAP :对照组在结扎后明显降低 (P <0 0 1) ,曲马多组结扎前后变化不明显。NO值 :对照组在结扎后较基础明显降低 (P <0 0 5 ) ,曲马多组在结扎后与基础值相比差异无显著性 ,曲马多组在结扎后 3h与基础的差值明显高于对照组同时点的差值 (P <0 0 1) ,在结扎后 6h与基础的差值 2组差异不显著。结论 心肌梗死急性期曲马多可以升高循环血中NO水平 ,对心肌具有保护作用
Objective To investigate the protective effects of tramadol on acute myocardial infarction in rabbits. Methods Twenty-six rabbits of 5 ~ 3kg were randomly divided into 2 groups: control group: the left diagonal branch of coronary artery was simply ligated; Tramadol group: 10 mg of tramadol 10 min before ligation, And 3h after ligation equal supplement. Mean arterial pressure (MAP) was monitored by puncture of the left femoral artery in each group, and the external jugular venous blood was collected at 3 h after administration and at baseline, 3 h after ligation and 6 h after ligation. Blood levels of nitric oxide (NO) content. Results MAP: The control group decreased significantly after ligation (P <0.01), while the changes were not obvious in the tramadol group before and after ligation. The NO value in the control group was significantly lower than that in the control group (P <0.05), but there was no significant difference between the tramadol group and the baseline value after ligation Which was significantly higher than that of the control group at the same time (P <0.01). There was no significant difference between the two groups at 6h after ligation and the baseline difference. Conclusion Tramadol in the acute stage of myocardial infarction can increase NO level in circulating blood and has a protective effect on myocardium