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目的:研究高温高压后的壳聚糖/甘油磷酸钠凝胶温敏、释药性能。方法:观察不同比例的壳聚糖和甘油磷酸钠混合液的凝胶时间、p H值变化。粘度测试比较不同比例壳聚糖/甘油磷酸钠混合液粘度变化。在37℃形成凝胶后,观察该体系作为奥硝唑药物模型载体的释药性能。结果:随着壳聚糖/甘油磷酸钠混合液中甘油磷酸钠的比例增加,溶液p H值增加,在37℃下,壳聚糖/甘油磷酸钠凝胶时间缩短,但当壳聚糖/甘油磷酸比例为2:1、1:1时,溶液不凝胶。粘度实验表明,4种比例(9:1、8:1、7:1、6:1)壳聚糖/甘油磷酸溶液随着时间增加,粘度明显增加,到10 min后粘度基本不变化,9:1比例组粘度最大为(53±0.9)Pa·s。药物释放实验表明,以奥硝唑为释药模型,该凝胶可持续释放200 min以上。结论:改进消毒方法后的壳聚糖/甘油磷酸钠,增加甘油磷酸钠比例可以提高溶液p H值,可在37℃下快速形成凝胶。该凝胶具有温敏性,具有缓慢释放药物能力。
Objective: To study the temperature-sensitive and drug-releasing properties of chitosan / glycerophosphate gel after high temperature and high pressure. Methods: The gelation time and p H value of different proportions of chitosan and sodium glycerophosphate were observed. Viscosity test to compare the different proportion of chitosan / glycerol sodium phosphate mixture viscosity changes. After gel formation at 37 ° C, the drug release behavior of the system as a vector for the ornidazole drug was observed. Results: With the increase of the proportion of sodium glycerophosphate in the mixture of chitosan / glycerophosphate, the pH of the solution increased and the chitosan / glycerophosphate gel time shortened at 37 ℃. However, when the ratio of chitosan / When the ratio of glycerophosphate is 2: 1, 1: 1, the solution does not gel. Viscosity experiments showed that the viscosity of chitosan / glycerophosphate solution with four ratios (9: 1, 8: 1, 7: 1, 6: 1) increased with time and the viscosity did not change after 10 min. : 1 ratio of the maximum viscosity of (53 ± 0.9) Pa · s. Drug release experiments showed that with ornidazole as the drug release model, the gel sustained release of 200 min or more. Conclusion: After improving the chitosan / sodium glycerophosphate after disinfection, increasing the ratio of glycerophosphate can increase the p H value of the solution, and the gel can be quickly formed at 37 ℃. The gel is thermo-sensitive and has the ability to slowly release the drug.