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目的：为了探讨弓形虫（ＴＯ），风疹病毒（ＲＶ），巨细胞病毒（ＣＭＶ）和单纯疱疹病毒Ⅱ（ＨＳＶⅡ）感染与先天性唇腭裂发生的关系。方法：对１２０例２月龄至１０岁唇腭裂病儿和６２名正常儿童血清抗ＴＯ－ＩｇＭ，抗ＲＶ－ＩｇＭ，抗ＣＭＶ－ＩｇＭ和抗ＨＳＶⅡ－ＩｇＭ用ＥＬＩＳＡ法作检。结果：病儿阳性率分别为４．２％，３．３％，３３．３％和３．３％，正常儿分别为１．６％，３．２％，２１．０％和３．３％，两者统计学上无显著差异。２～３月龄组病儿抗ＣＭＶ－ＩｇＭ阳性率为４３．８％，显著高于正常儿的９．１％（Ｐ＜０．０５）。结论：唇腭裂的发生与ＴＯ，ＲＶ和ＨＳＶⅡ感染可能无明显关系，与先天性ＣＭＶ感染有一定关系。
Objective: To investigate the relationship between toxoplasma (TO), rubella virus (RV), cytomegalovirus (CMV) and herpes simplex virus (HSV Ⅱ) infection and congenital cleft lip and palate. Methods: Serum anti-TO-IgM, anti-RV-IgM, anti-CMV-IgM and anti-HSVII-IgM were detected by ELISA in 120 children aged 2 months to 10 years with cleft lip and palate and 62 normal children. Results: The positive rates of sick children were 4.2%, 3.3%, 33.3% and 3.3% respectively, while the normal children were 1.6%, 3.2%, 21.0% and 3.3 %, No statistically significant difference between the two. The positive rate of anti-CMV-IgM in children aged 2 ~ 3 months was 43.8%, significantly higher than that of normal children (9.1%, P <0.05). Conclusion: The occurrence of cleft lip and palate may not be related to TO, RV and HSV Ⅱ infection, and may be related to congenital CMV infection.