用成年雄性家兔49只,分为正常组、溃疡组和盐水组。正常组是未经处理的正常家兔;溃疡组为在无菌条件下,打开动物腹腔,用少量冰醋酸注入胃粘膜下层,造成实验性胃溃疡;盐水组模拟手术,用生理盐水注入胃粘膜下层。手术后1～28天,分批取甲状腺,进行组织学和组织化学的观察。实验结果表明,各组甲状腺滤泡旁细胞没有明显的组织学变化。正常家兔甲状腺滤泡旁细胞的乙酰胆碱酯酶、非特异性酯酶和酸性磷酸酶反应很强,乙酰胆碱酯酶有一定的特异性;硫胺素焦磷酸酶反应很弱;琥珀酸脱氢酶、乳酸脱氢酶和葡萄糖-6-磷酸脱氢酶反应弱阳性。盐水组的甲状腺滤泡旁细胞在手术后1～7天,某些组织化学产生一定的变化;在手术后14～28天恢复正常。溃疡组的甲状腺滤泡旁细胞在手术后1～3天,各组织化学反应与盐水组相似;手术后7～28天,许多组织化学反应均在一定程度上比盐水组的反应增强。本文讨论了以上组织化学变化的意义,提示在实验性胃溃疡期间,甲状腺滤泡旁细胞可能参与了调节活动。 49 adult male rabbits were divided into normal group, ulcer group and saline group. The normal group was untreated normal rabbits; in the aseptic group, under aseptic conditions, the abdominal cavity of the animals was opened, and a small amount of glacial acetic acid was injected into the submucosa of the stomach to cause experimental gastric ulcer; the saline group was simulated and the saline was injected into the gastric mucosa. Lower level. One to 28 days after surgery, thyroid glands were taken in batches for histological and histochemical observation. The experimental results showed that there were no obvious histological changes in the thyroid parafollicular cells in each group. Normal rabbit thyroid follicular cells are highly reactive with acetylcholinesterase, non-specific esterase and acid phosphatase, acetylcholinesterase has a certain specificity; thiamine pyrophosphatase reaction is weak; succinate dehydrogenase, Lactate dehydrogenase and glucose-6-phosphate dehydrogenase reactions are weakly positive. The thyroid parafollicular cells in the saline group had certain changes in histochemistry at 1 to 7 days after surgery and returned to normal at 14 to 28 days after surgery. The thyroid follicular cells in the ulcer group were similar to those in the saline group 1 to 3 days after surgery. The response of many histochemical reactions to the saline group was greater at 7 to 28 days after surgery. This article discusses the significance of the above histochemical changes, suggesting that parathyroid follicular cells may be involved in regulatory activities during experimental gastric ulcers.